What question did this study set out to answer?

This research aims to evaluate the effectiveness of triple therapy in promoting virilization and reducing hormone requirements in males with congenital hypogonadotropic hypogonadism.

April 5, 2026SHILAP Revista de lepidopterologíaOpen Access

Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial

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This research aims to evaluate the effectiveness of triple therapy in promoting virilization and reducing hormone requirements in males with congenital hypogonadotropic hypogonadism.
Conducted an open-label randomized controlled trial with three treatment groups.
Group A received triple therapy; Group B received combined hCG and FSH; Group C received hCG monotherapy initially.
Primary outcomes measured included hCG/FSH doses required for spermatogenesis induction and time to achieve spermatogenesis.
Spermatogenesis achieved in 84.6% of Group A, compared to 69.2% in Group B and 75% in Group C (p=0.648).
Median hCG dose for spermatogenesis was 7500 IU/week in Group A, compared to 9000 IU/week in Groups B and C (p=0.016).
Time to spermatogenesis was similar across groups: 12 months for Groups A and B, 15 months for Group C (p=0.345).

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A randomized controlled trial compares the effectiveness of triple therapy versus conventional treatment in male congenital hypogonadotropic hypogonadism, suggesting better outcomes with triple...

Cite This Study

Konsam et al. (2026) studied this question.

synapsesocial.com/papers/69d1fb20a79560c99a0a1895 https://doi.org/10.3389/fendo.2026.1777584

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Implication

A randomized controlled trial compares the effectiveness of triple therapy versus conventional treatment in male congenital hypogonadotropic hypogonadism, suggesting better outcomes with triple...

Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial

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Discussion

Implication

Cite This Study

Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial

Key Points

Discussion

Implication

Cite This Study

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