What question did this study set out to answer?

The research aims to evaluate the optimisation of methotrexate treatment before escalation to biologics in patients with rheumatoid arthritis.

April 5, 2026EULAR Rheumatology OpenOpen Access

Real-world epidemiology and management of patients with rheumatoid arthritis treated with methotrexate in France: a decade after methotrexate first recommendations

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Authors

RFRené-Marc FlipoLille’s Cardiology Hospital DJDenis JullienHospices Civils de Lyon LCLouis ChillottiGeosciences Consultants

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Implication

Observational cohort study assesses methotrexate optimisation and its economic impact in patients with rheumatoid arthritis, highlighting implications for treatment strategies.

Key Points

The research aims to evaluate the optimisation of methotrexate treatment before escalation to biologics in patients with rheumatoid arthritis.
Used claims data from the French national insurance database.
Identified patients with rheumatoid arthritis who initiated methotrexate between 2016 and 2021.
Followed patients initiating methotrexate in 2016-2017 to assess efficacy and costs associated with treatment escalation.
52,462 patients initiated methotrexate, with a two-year persistence rate of 73.7%.
17.5% escalated to biologics, with many not fully optimised on methotrexate prior to escalation.
Mean costs increased significantly from €6218 before escalation to €13,131 after.

Cite This Study

Flipo et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc4fa79560c99a0a1ea7 https://doi.org/10.1016/j.ero.2026.03.003

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Implication

Observational cohort study assesses methotrexate optimisation and its economic impact in patients with rheumatoid arthritis, highlighting implications for treatment strategies.

Real-world epidemiology and management of patients with rheumatoid arthritis treated with methotrexate in France: a decade after methotrexate first recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

Real-world epidemiology and management of patients with rheumatoid arthritis treated with methotrexate in France: a decade after methotrexate first recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

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