Plasma PAI-1 Levels Increase in Colorectal Cancer Compared to Benign Colonic Disease
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Key Points
This research aims to compare preoperative plasma levels of PAI-1 in colorectal cancer patients and those with benign colonic disease.
Prospective enrollment of patients undergoing colorectal resection for either benign or cancerous conditions.
Measurement of plasma PAI-1 levels using ELISA and analysis of PAI-1 expression in tumor and normal tissues via QRT-PCR and immunohistochemistry.
Statistical analysis using Mann-Whitney test and ROC curve for diagnostic evaluation.
Average plasma PAI-1 levels were significantly higher in colorectal cancer patients (11.75 ng/ml) compared to benign colonic disease patients (2.95 ng/ml).
Higher PAI-1 mRNA expression found in 50% of colorectal cancer samples compared to paired normal tissues.
The AUC for PAI-1 as a diagnostic marker was 0.759, with sensitivity at 68% and specificity at 77%.
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Implication
Research demonstrates elevated plasma PAI-1 in colorectal cancer patients, indicating its potential diagnostic importance.
Cite This Study
Mudiyanselage et al. (2026) studied this question.