Key result
Minimally invasive colorectal resection linked to a ~30% increase in postoperative plasma Neuropilin-1 levels.
Why the study?
Elevated Neuropilin-1 (NRP1) is linked to colorectal cancer progression, but the impact of surgery on blood levels of NRP1 is poorly studied.
Does minimally invasive colorectal resection affect plasma Neuropilin-1 levels in patients with colorectal cancer?
Population
92 CRC patients undergoing minimally invasive colorectal resection
Comparison
Postoperative intervals vs preoperative baseline
Design
Observational study using a data/plasma bank
Follow-up
Up to POD 28-41
Authors
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May promote residual tumor angiogenesis after colorectal resection; hypothesis-generating for anti-NRP1 therapy before practice change.
Observational (n=92)
Does minimally invasive colorectal resection affect plasma Neuropilin-1 levels in patients with colorectal cancer?
Absolute Event Rate: 384.3% vs 296%
p-value: p=<0.0001
Plasma Neuropilin-1 levels are significantly and persistently elevated for up to a month following minimally invasive colorectal cancer resection, which may promote angiogenesis in residual tumor deposits.
Mudiyanselage et al. (2026) conducted an observational in Colorectal cancer (n=92). Minimally invasive colorectal resection vs. Preoperative baseline was evaluated on Plasma Neuropilin-1 (NRP1) levels (p=<0.0001). Minimally invasive colorectal resection for colorectal cancer significantly increased plasma Neuropilin-1 levels from a preoperative mean of 296.0 ng/ml to 384.3 ng/ml on postoperative day 3 (p<0.0001).
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