Key result
Minimally invasive colorectal resection is associated with significantly elevated plasma VEGF and Ang-2 levels for 2 to 4 weeks, stimulating endothelial cell growth, invasion, and migration.
Why the study?
Does minimally invasive colorectal resection for cancer cause persistent proangiogenic plasma protein changes?
Population
105 patients undergoing minimally invasive colorectal resection (MICR) for cancer
Comparison
Minimally invasive colorectal resection (MICR) vs Preoperative baseline (preop plasma)
Design
Cohort
Follow-up
up to 2 months
Authors
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May promote residual tumor growth post-resection; hypothesis-generating for recurrence and survival with minimally invasive approaches.
Observational (n=105)
Does minimally invasive colorectal resection for cancer cause persistent proangiogenic plasma protein changes?
Minimally invasive colorectal resection is associated with persistent proangiogenic plasma changes for 2 to 4 weeks that stimulate endothelial cell growth, invasion, and migration in vitro, potentially promoting residual tumor growth.
Kumara et al. (2009) conducted an observational in Colorectal cancer (n=105). Minimally invasive colorectal resection vs. Preoperative baseline was evaluated on Plasma VEGF, Ang-1, and Ang-2 levels and in vitro endothelial cell behavior. Minimally invasive colorectal resection is associated with significantly elevated plasma VEGF and Ang-2 levels for 2 to 4 weeks, stimulating endothelial cell growth, invasion, and migration.
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