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Demonstrates that CRISPR-mediated disruption of MLH1 inhibits tumor growth in endometrial cancer, suggesting new treatment avenues.
In EC cells with pre-existing MLH1 promoter methylation, MLH1-KD leads to MSI-H, enhances genomic instability, disrupts Wnt signaling, impairs cellular functions, and inhibits tumor growth, highlighting Wnt signaling and MSI-H as potential therapeutic targets in EC.
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Xing et al. (2026) studied this question.
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