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This research aims to investigate the role of gut bacteria in pancreatic cancer metastasis.

Obligate Anaerobes Drive Pancreatic Cancer Metastasis via Tumoral Microbiota

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This research aims to investigate the role of gut bacteria in pancreatic cancer metastasis.
Established a gnotobiotic system with a curated human gut microbiota library.
Administered bacteria via oral gavage in germ-free mice followed by cancer cell injections.
Performed 16S sequencing and culture-based propagation of tumor-associated bacteria.
Clostridium species were enriched in cancerous tissues compared to non-cancerous controls.
Co-injections of Clostridium with cancer cells increased liver metastasis over ten-fold.
Bacteria-derived factors from Clostridium enhanced cancer spread, indicating their pro-metastatic role.

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Experimental system identifies bacteria influencing cancer spread in gnotobiotic mice, suggesting new therapeutic options.

Zingone et al. (2026) studied this question.

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