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This research aims to explore how gut-derived microbes support cancer stem cell maintenance and promote pancreatic cancer progression.

Gut Bacteria Influence Stemness Maintenance in Pancreatic Cancer Progression

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This research aims to explore how gut-derived microbes support cancer stem cell maintenance and promote pancreatic cancer progression.
Conducted clinical profiling of pancreatic ductal adenocarcinoma samples to identify microbial species.
Utilized 16S rRNA FISH and LPS staining to localize bacteria in human and mouse PDAC tissues.
Exposed PDAC and normal pancreatic cell lines to bacterial supernatants, live bacteria, and LPS for functional analysis.
Applied omics integration to characterize microbial metabolites and their pathways impacting cancer stem cells.
Conducted in-vivo studies on genetically engineered mice to assess microbiome depletion effects on CSC dynamics and tumor progression.
Basal-like PDAC subtype showed enrichment of specific bacteria linked to tumor aggressiveness.
Bacterial accumulation in tumors was observed, correlating with disease stage.
Exposure to bacterial components significantly elevated cancer stem cell markers and enhanced self-renewal.
Antibiotic treatment reduced cancer stem cell markers in mouse models, indicating lowered CSC maintenance.

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Investigates gut bacteria's role in enhancing cancer stem cell maintenance in pancreatic cancer, suggesting new therapeutic targets.

Arikath et al. (2026) studied this question.

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