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April 5, 2026

Reduced Frontal White Matter Hyperintensities in Superagers: Evidence of Resistance to Age-Related Structural Brain Changes.

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Authors

LGLaiz Laura de GodoyCSCarole H SudreASAdalberto Studart-Neto

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Overview

Demonstrates reduced frontal white matter hyperintensities in superagers, suggesting a neuroprotective effect against age-related brain changes.

Key Points

  • The aim is to investigate the burden of frontal white matter hyperintensities (WMH) in superagers and their relationship to cognitive performance.
  • Utilized a novel regional mapping approach for detailed analysis of white matter hyperintensities.
  • Compared WMH burden in superagers to typical aging populations.
  • Focused on specific brain regions like juxtacortical and mid-white matter layers.
  • Superagers exhibited significantly lower burdens of frontal WMH compared to age-matched individuals.
  • Reduced WMH in strategic brain areas correlates with preserved cognitive abilities in superagers.
  • The study identifies potential neuroimaging markers associated with the superager-resistant phenotype.

Cite This Study

Godoy et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcfda79560c99a0a2cb5https://doi.org/10.3174/ajnr.a9084
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