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This research aims to identify and characterize tumor-specific matrisome signatures in various cancers, facilitating therapeutic targeting.

Characterizing Tumor Microenvironment Using Matrisome-Based Platform

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This research aims to identify and characterize tumor-specific matrisome signatures in various cancers, facilitating therapeutic targeting.
Utilized a decellularization protocol to preserve ECM structure during analysis of tumor samples.
Characterized the matrisome in pancreatic ductal adenocarcinoma and colorectal cancer through histological and proteomic analyses.
Employed TMT DDA mass spectrometry to identify proteins in the decellularized ECM samples.
Identified 1,080 proteins in colorectal cancer samples, with 83 and 96 ECM proteins differentially expressed in CRC and CRC-LM, respectively.
Detected 854 proteins in PDAC tumors, including 103 core matrisome proteins, revealing a distinct tumor-specific ECM signature.
Highlighted ultra-selective ECM targets that may serve as candidate therapeutic targets based on transcriptomic integration.

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Analysis uncovers novel ECM targets in cancer, suggesting pathways for new therapeutic approaches.

Long et al. (2026) studied this question.

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