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April 5, 2026Cancer Research

Spatial Transcriptomic Predictors of Immune Checkpoint Blockade in Advanced Gastric Cancer

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Authors

CHChangjin HongSPSunho ParkJCJean R. Clemenceau

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Overview

Spatial transcriptomic analysis identifies predictors of immune checkpoint blockade response in advanced gastric cancer, suggesting actionable therapeutic targets.

Key Points

  • The research aims to identify spatial transcriptomic signatures that predict immune checkpoint blockade outcomes in advanced gastric cancer.
  • Profiled pre-treatment samples from advanced gastric cancer patients treated with immune checkpoint blockade using spatial transcriptomics.
  • Derived spatial signatures representing immune, stromal, and tumor compartments to assess their association with treatment non-response.
  • Validated findings across multiple datasets, including bulk RNA-seq and single-cell RNA-seq cohorts.
  • Non-responders exhibited distinct spatial immune signatures, including Th2 and regulatory Th17 programs.
  • Stromal signatures linked to non-responders involved inflammatory CAFs and complement system activation.
  • Spatial analysis revealed reduced T-cell infiltration and specific immune microenvironment characteristics in non-responders.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a308ehttps://doi.org/10.1158/1538-7445.am2026-3957
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4947: Spatially organized transcriptional programs and tumor-stroma interfaces shape immunotherapy response in microsatellite instability-high gastrointestinal cancers2026
  2. 2Abstract LB122: Dynamic interactions of spatially organized tumor, stromal and immune cellular niches predict outcome to immune checkpoint blockade (ICB) in recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC)2026
  3. 3Abstract 3435: Spatial transcriptomic profiling reveals distinct tumor microenvironment remodeling patterns associated with immune checkpoint blockade response in lung adenocarcinoma2026
  4. 4Abstract 1141: Spatial-specific gene signatures to predict immunotherapy outcomes in lung cancer2024
  5. 5Abstract 1420: Image-based ROI selection for spatial transcriptomic experiments using immune checkpoint inhibitor treatment outcome prediction in gastric cancer.2026