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April 5, 2026Cancer Research

Abstract 1177: Prognostic implications of circulating Hepsin in prostate cancer.

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Authors

TWTaylor D. WadleyACAdam ColeBJBlake Johnson

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Overview

Prognostic analysis reveals circulating Hepsin identifies risk of biochemical recurrence in prostate cancer, indicating its clinical relevance.

Key Points

  • This research aims to assess the clinical relevance of circulating Hepsin as a biomarker for prostate cancer progression and outcomes.
  • Developed a quantitative sandwich ELISA for detecting circulating Hepsin.
  • Conducted retrospective analyses of 543 patients undergoing prostate evaluation.
  • Assessed clinicopathologic variables between Hepsin-positive and -negative groups.
  • Analyzed biochemical recurrence-free survival among RALP patients using Kaplan-Meier and Cox regression.
  • Circulating Hepsin positivity was found in 20% of patients.
  • Hepsin-positive patients had significantly higher cancer incidence, advanced stage, and metastasis compared to Hepsin-negative patients.
  • Kaplan-Meier analysis indicated reduced recurrence-free survival with Hepsin positivity (log-rank p < 0.001).
  • Circulating Hepsin is an independent predictor of biochemical recurrence (p = 0.0001).
  • Hepsin positivity adds prognostic value in high CAPRA-S score patients.

Cite This Study

Wadley et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd62a79560c99a0a36aahttps://doi.org/10.1158/1538-7445.am2026-1177
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