Key result
Vertical transmission of Group B Coxsackieviruses linked to severe fetal malformations, stillbirth, and newborn mortality.
Why the study?
Vertical transmission of group B coxsackieviruses is an underestimated route associated with serious consequences, including abortion, stillbirth, congenital malformations, and newborn morbidity and mortality.
What are the mechanisms and consequences of vertical transmission of Group B Coxsackieviruses from mother to infant?
What are the mechanisms and consequences of vertical transmission of Group B Coxsackieviruses from mother to infant?
Vertical transmission of Group B Coxsackieviruses is an underestimated route that can lead to severe fetal and neonatal complications.
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May warrant heightened vigilance in maternal enteroviral infection; challenges underestimation of this neglected vertical transmission route.
Group B Coxsackieviruses (CV‐B), like other enteroviruses, are essentially transmitted from person to person through the faecal‐oral route. However, vertical transmission from mother to infant, through transplacental passage or inhalation of contaminated cervical swabs during delivery, can also occur. This underestimated route of CV‐B transmission has been associated with serious consequences, mainly abortion, stillbirth, congenital malformations, as well as serious morbidity and mortality in the newborns. Based on a systematic review of clinical observations, this paper explains the mechanisms of CV‐B vertical transmission and its diverse consequences, with a special focus on associated diseases. Preventive measures, therapeutic strategies, and recommendations are also addressed.
Halouani et al. (2026) studied this question. Vertical transmission of Group B Coxsackieviruses from mother to infant is associated with severe consequences including abortion, stillbirth, congenital malformations, and newborn mortality.
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