Key result
Intrafamilial transmission of coxsackievirus B3 led to vertical transmission, causing severe early-onset neonatal hepatitis, disseminated intravascular coagulation, and prolonged viral RNA shedding.
Case Report (n=3)
Mild household coxsackievirus B3 infections can lead to vertical transmission with severe consequences for infants, including severe hepatitis, disseminated intravascular coagulation, and prolonged viral shedding.
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Alerts to severe neonatal hepatitis risk from household coxsackievirus B3; case report leaves open prospective validation of vertical transmission.
Cheng et al. (2006) conducted a case report in Coxsackievirus B3 infection (n=3). Coxsackievirus B3 infection was evaluated. Intrafamilial transmission of coxsackievirus B3 led to vertical transmission, causing severe early-onset neonatal hepatitis, disseminated intravascular coagulation, and prolonged viral RNA shedding.
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