Maternal vitamin D, cord blood cytokines, and early childhood allergic diseases: a 2-year cohort study.

Zheng Zhang; Tao Zhan; Jiahui Hu; Yongxing Zhong

doi:10.1016/j.jped.2026.101544

March 30, 2026

Maternal vitamin D, cord blood cytokines, and early childhood allergic diseases: a 2-year cohort study.

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Key Points

To explore the association between maternal vitamin D levels and the risk of allergic diseases in early childhood, with a focus on cord blood cytokines.
Conducted a 2-year cohort study
Measured maternal vitamin D levels during pregnancy
Analyzed cytokines in umbilical cord blood
Evaluated allergic disease outcomes in early childhood
Higher maternal vitamin D levels correlated with lower allergic disease risk in offspring
Cytokines interleukin-4 and interleukin-10 were identified as potential mediators
Findings suggest that vitamin D impacts immune system development through cytokine regulation

Implication

Cohort study examines vitamin D's effect on allergy risk in children, suggesting cytokines play a role.

Abstract

Normal maternal prenatal vitamin D status is tied to lower allergic disease risk in offspring, with umbilical cord blood cytokines (especially interleukin-4 and interleukin-10) potentially mediating this relationship in early childhood.

Discussion

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe07a79560c99a0a46f2 https://doi.org/10.1016/j.jped.2026.101544

View Full Paper

Ask AI

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Maternal vitamin D, cord blood cytokines, and early childhood allergic diseases: a 2-year cohort study.

Key Points

Implication

Abstract

Discussion

Cite This Study

Maternal vitamin D, cord blood cytokines, and early childhood allergic diseases: a 2-year cohort study.

Key Points

Implication

Abstract

Discussion

Cite This Study

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