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April 5, 2026Cancer Research

Abstract 669: Development and characterization of a patient-derived liver organoid biobank for toxicology and functional studies.

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Authors

RBRudra BhowmickBOBenjamen O'DonnellFPFong Cheng Pan

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Overview

Develops a liver organoid biobank for toxicology and functional studies, suggesting it enhances drug testing efficacy.

Key Points

  • The aim is to develop a patient-derived liver organoid biobank to better model liver biology and toxicity.
  • Collected liver tissues with donor consent.
  • Created organoids using minced and digested tissue cultured in specific media.
  • Expanded and cryopreserved 11 individual liver PDO lines.
  • Validated organoid lines for unique identification and freedom from infectious agents.
  • All PDO lines expressed liver-specific biomarkers and confirmed functional maturity.
  • Lines exhibited increased albumin and urea production along with inducible cytochrome P450 activity.
  • Donor-dependent variability in phenotypes indicates relevance to patient population.
  • Evaluated four PDO lines for response to 3 drugs linked to drug-induced liver injury.

Cite This Study

Bhowmick et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe18a79560c99a0a49dchttps://doi.org/10.1158/1538-7445.am2026-669
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