Effect of oxycodone vs . morphine as first‐line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study

Key Points

• To evaluate whether morphine as the first-line opioid reduces new persistent opioid use compared to oxycodone after orthopaedic surgery.
• Conducted a prospective sequential cohort study
• Compared the effects of oxycodone and morphine as first-line opioids
• Assessed patterns of new persistent opioid use and analgesia effectiveness
• No significant reduction in new persistent opioid use with morphine compared to oxycodone
• Both opioids provided comparable levels of pain relief (analgesia)