HIIT alters muscle-nonspecific microRNAs in obese older adults, suggesting biomarkers for response.
HIIT did not impact the expression level of myo-microRNAs and muscle-related microRNAs but induced changes in muscle-nonspecific microRNAs in muscle biopsy and serum. Modulations of microRNAs in muscle (miR-504-5p, -744-5p) and serum (miR-151a-3p, -4433b-5p, -106b-5p) were associated with HIIT's beneficial effects, suggesting their role in the HIIT effects and their potential as candidate biomarkers for response.
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Mercier‐Guery et al. (2026) studied this question.
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