What question did this study set out to answer?

This research aims to explore how 12-week high-intensity interval training (HIIT) affects microRNA levels in skeletal muscle and serum of obese older adults.

April 6, 2026Journal of Cachexia Sarcopenia and Muscle0 citationsOpen Access

Skeletal Muscle and Circulating microRNAs Adaptations to 12‐Week HIIT With or Without L‐Citrulline in Obese Older Adults

AMAlexandre Mercier‐GueryUniversité Claude Bernard Lyon 1 MMM. MilletUniversité Claude Bernard Lyon 1 MCMartine CrosetUniversité Claude Bernard Lyon 1

Key Points

This research aims to explore how 12-week high-intensity interval training (HIIT) affects microRNA levels in skeletal muscle and serum of obese older adults.
Participants engaged in 12 weeks of high-intensity interval training (HIIT).
MicroRNA levels were measured in muscle biopsies and serum samples.
Comparison made between groups with and without L-citrulline supplementation.
HIIT did not significantly change muscle-related microRNAs.
Changes in muscle-nonspecific microRNAs (like miR-504-5p, -744-5p) were observed post-HIIT.
Serum levels of microRNAs (miR-151a-3p, -4433b-5p, -106b-5p) were associated with HIIT benefits.

Abstract

HIIT did not impact the expression level of myo-microRNAs and muscle-related microRNAs but induced changes in muscle-nonspecific microRNAs in muscle biopsy and serum. Modulations of microRNAs in muscle (miR-504-5p, -744-5p) and serum (miR-151a-3p, -4433b-5p, -106b-5p) were associated with HIIT's beneficial effects, suggesting their role in the HIIT effects and their potential as candidate biomarkers for response.

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