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November 8, 1956New England Journal of Medicine167 citations

Acute Aseptic Myocarditis and Meningoencephalitis in the Newborn Child Infected with Coxsackie Virus Group B, Type 3

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SKSidney KibrickBoston UniversityKBKurt BenirschkeUniversity of California, San Diego

Key Points

  • Document clinical and virological evidence of transplacental intrauterine transmission of Coxsackie virus Group B, Type 3 causing fatal neonatal disease.
  • Evaluated the clinical history and pathological findings of an infant delivered via cesarean section who died at seven days of life.

Structured PICO

P
Population
Newborn infant with acute myocarditis and meningoencephalitis following intra-uterine infection with Coxsackie virus Group B, Type 3
O
Outcome
Clinical course and post-mortem virologic/pathological findings

This case report provides evidence of fatal intra-uterine infection with Coxsackie virus Group B, Type 3 causing acute myocarditis and meningoencephalitis in a newborn.

Abstract

THIS paper presents evidence for intra-uterine infection with a Coxsackie virus Group B, Type 3, in an infant in whom acute myocarditis and meningoencephalitis developed. The infant was delivered by cesarean section and died seven days later. The virus was recovered post mortem from the thoracic spinal cord. The clinical history, along with pertinent pathological and virologic findings, is presented, with a discussion of their significance.Case ReportThe patient's mother, a 37-year-old para III, gravida IV, was well until the 38th week of pregnancy, when an upper respiratory infection characterized by coryza, sneezing and malaise developed. The temperature was . . .

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Cite This Study

Kibrick et al. (1956) studied this question.

synapsesocial.com/papers/69d3d646acaafb5a09974dc9https://doi.org/10.1056/nejm195611082551902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fourteen Cases of Idiopathic Myocarditis in Infants and Children1953 · 30 citations
  2. 2LESIONS CAUSED IN SUCKLING MICE BY CERTAIN VIRUSES ISOLATED FROM CASES OF SO CALLED NON-PARALYTIC POLIOMYELITIS AND OF PLEURODYNIA1950 · 81 citations
  3. 3QUANTITATIVE STUDIES OF THE VIRUS-HOST RELATIONSHIP IN CHIMPANZEES AFTER INAPPARENT INFECTION WITH COXSACKIE VIRUSES1953 · 26 citations
  4. 4An Evaluation of the Roller-Tube Tissue Culture for the Isolation of Poliomyelitis Viruses from Feces1955 · 26 citations
  5. 5Interstitial Myocarditis in Children1951 · 33 citations