What is the clinical evidence from this study?

Study design: Case Report. Population: Serious Coxsackie Infection (n=3). Intervention: Coxsackie Group B Type 4 virus infection.

What question did this study set out to answer?

To investigate severe infections caused by coxsackie virus, particularly leading to myocarditis in infants.

September 1, 1958A M A Journal of Diseases of Children

Serious Coxsackie Infection in Infants and Children

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Key result

Coxsackie Group B Type 4 virus infection was identified as the cause of fatal myocarditis and sepsis in two infants, and reversible myocarditis in a 5-year-old boy.

Population

3 infants and children with serious Coxsackie Group B Type 4 infection

Design

Case_series

Authors

DHDon M. HosierNationwide Children's Hospital

Discussion

Member takes

Implication

Clinicians should test for Coxsackie B in unexplained neonatal myocarditis; leaves open incidence, transmission, and prevention strategies.

Key Points

To investigate severe infections caused by coxsackie virus, particularly leading to myocarditis in infants.
Isolation of coxsackie Group B Type 4 virus from the myocardium during autopsy
Examined cases of infants who died from heart failure and sepsis
Reported cases included both newborns and older children recovering from myocarditis.
Five fatalities from myocarditis linked to Coxsackie virus types B-3 or B-4 documented
Successful recovery in a 5-year-old boy from myocarditis associated with Group B Type 4 virus
Link identified between myocarditis cases and prior epidemics of pleurodynia or aseptic meningitis.

Study Design

Type

Case Report (n=3)

Structured PICO

Population

Three pediatric cases (a 14-day-old, a 7-week-old, and a 5-year-old) presenting with serious Coxsackie Group B Type 4 infection, including fatal myocarditis and sepsis.

Outcome

Clinical outcome (death or recovery) and viral isolation

This report provides evidence that Coxsackie Group B Type 4 virus can cause fatal myocarditis and sepsis in infants during nonepidemic periods.

Cite This Study

Don M. Hosier (1958) conducted a case report in Serious Coxsackie Infection (n=3). Coxsackie Group B Type 4 virus infection was evaluated. Coxsackie Group B Type 4 virus infection was identified as the cause of fatal myocarditis and sepsis in two infants, and reversible myocarditis in a 5-year-old boy.

synapsesocial.com/papers/6a62db02aca57fe9652869f0 https://doi.org/10.1001/archpedi.1958.02060060253001

Topics

Myocarditis

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Implication

Clinicians should test for Coxsackie B in unexplained neonatal myocarditis; leaves open incidence, transmission, and prevention strategies.

Serious Coxsackie Infection in Infants and Children

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Serious Coxsackie Infection in Infants and Children

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Topics

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