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April 7, 2026Pediatric Hematology and Oncology

Nationwide survey of ruxolitinib administration for Japanese children with hemophagocytic lymphohistiocytosis

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Authors

KTKéiichi TanakaRORintaro OnoTDTakehiko Doi

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Overview

A nationwide survey evaluates ruxolitinib's effectiveness in treating pediatric HLH, indicating its potential as a therapy.

Key Points

  • To assess the use and effectiveness of ruxolitinib in treating pediatric HLH in Japan.
  • Nationwide, multicenter survey
  • Retrospective study design
  • Inclusion of 17 pediatric patients from 9 institutions
  • Ruxolitinib administered for refractory disease and maintenance therapy
  • 80% overall response rate for primary HLH/EBV-HLH
  • 89% overall response rate for post-transplant HLH
  • Sustained remission achieved in three patients receiving maintenance therapy, with two avoiding transplantation.

Cite This Study

Tanaka et al. (2026) studied this question.

synapsesocial.com/papers/69d49ecbb33cc4c35a22784fhttps://doi.org/10.1080/08880018.2026.2653020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HLHRUXO: A prospective trial of a ruxolitinib-containing regimen for children with hemophagocytic lymphohistiocytosis2026
  2. 2Retrospective analysis of ruxolitinib as induction treatment in pediatric hemophagocytic lymphohistiocytosis2025 · 1 citations
  3. 3Accelerated response and reduced chemotherapy with ruxolitinib-based regimen therapy in pediatric hemophagocytic lymphohistiocytosis: a retrospective comparison with HLH-94 regimen2026 · 1 citations
  4. 4Ruxolitinib in malignancy-associated hemophagocytic lymphohistiocytosis (M-HLH): A systematic literature review2025
  5. 5Differential efficacy and safety of ruxolitinib in primary versus secondary hemophagocytic lymphohistiocytosis: a systematic review and meta-analysis2026