Risk Factors for Anti-Glaucoma Surgery in Posner-Schlossman Syndrome Patients: an 8-Year Retrospective Study

This study identifies older age, higher attack frequency and RNFL defect as risks for anti-glaucoma surgery in 106 Chinese Posner-Schlossman Syndrome (PSS) patients via an 8-year retrospective study.Purpose: To investigate the risk factors for anti-glaucoma surgery in Chinese patients with PSS.Patients and Methods: Retrospective study.All PSS patients visiting Peking University Third Hospital Department of Ophthalmology between June 2016 and May 2023 with a minimum follow-up of 12 months were enrolled.Patients were divided into low-frequency group and high-frequency group (whether average attacks were less than 2 times/year or not).General information, ocular manifestation and medical treatment were compared between the two groups.Risk factors for anti-glaucoma surgery were analyzed.Results: Among 106 patients, 62 cases were in the low-frequency group and 44 were in the high-frequency group.Patients in high-frequency group had a longer duration of attacks, more iris atrophy, and systemic administration of ganciclovir (p=0.044,0.044, 0.012, respectively).They also had a higher tendency to develop secondary glaucoma and more probability of undergoing anti-glaucoma surgery (p=0.014,0.017 respectively).18 cases (17%) received anti-glaucoma surgery while binary logistic regression showed that the risk factors for receiving anti-glaucoma surgery were elder age of onset (odds ratio (OR)=1.080;95% confidence interval (CI): 1.012-1.153;p=0.021), higher frequency of attacks (OR=6.186;95% CI: 1.276, 29.976; p=0.024), and RNFL defect (OR=4.804;95% CI: 1.040, 22.184; p=0.044).Conclusion: Risk factors for anti-glaucoma surgery in patients with PSS were elder age of onset, higher frequency of attacks and RNFL defect.