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April 7, 2026PlantsOpen Access

The Green Treasure from Appennine Flora for Colon and Liver Health: Characterization and Evaluation of the Protective Effects from Aerial Parts of Helichrysum italicum

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Authors

MLMaria Loreta LiberoGGG.L. GenovesiMGMariachiara Gabriele

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Overview

Investigates the protective effects of Helichrysum italicum extracts on colon and liver health, suggesting therapeutic potential for inflammatory disorders.

Key Points

  • To study the phytochemical properties and biological effects of extracts from Helichrysum italicum.
  • Evaluated polar extracts (water and hydroalcoholic) from aerial parts of H. italicum.
  • Assessed phenolic composition and antioxidant/enzyme inhibitory activities.
  • Conducted eco-toxicological assays using Artemia salina and Daphnia magna.
  • Examined the effects on colon and liver tissues using an ex vivo inflammatory model.
  • Performed docking studies to explore potential mechanisms.
  • Hydroalcoholic extract showed higher phenol levels and significant antioxidant and enzyme inhibition.
  • Extracts mitigated LPS-induced COX-2 and IL-6 stimulation within 200–1000 µg/mL.
  • Phenolic compounds, including hydroxycinnamic acids and flavonoids, were identified as key active components.

Cite This Study

Libero et al. (2026) studied this question.

synapsesocial.com/papers/69d49f6bb33cc4c35a227dfdhttps://doi.org/10.3390/plants15071108
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  4. 4Antioxidant Compounds in Helichrysum italicum Distillation Waste: Preliminary Findings2026
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