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June 13, 2026Biomedical Chromatography

Solvent‐Dependent GC–MS and LC–MS/MS Phytochemical Profiling of Echium italicum L. Aerial Part Extracts and In Vitro Enzyme Inhibitory and DNA‐Protective Effects

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Authors

İGİçim GökkayaGSGökçe SeyhanEGElçin Güney

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Overview

Randomized trial evaluates enzyme inhibition and DNA protection in E. italicum extracts, suggesting solvent impact on phenolic profiles.

Key Points

  • This research aims to profile the phytochemicals of Echium italicum extracts and assess their biological activities.
  • Extracts were prepared using chloroform, ethyl acetate, ethanol, and 70% ethanol from aerial parts of E. italicum.
  • Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were utilized for phytochemical analysis.
  • In vitro enzyme inhibition assays and agarose gel electrophoresis were performed to evaluate antioxidant and DNA protective effects.
  • The 70% ethanol extract exhibited the strongest antioxidant activity (78.10% DPPH scavenging at 200 μg/mL).
  • This extract also showed the highest α-glucosidase inhibition (61.45% at 200 μg/mL).
  • No DNA strand breaks were induced, indicating protective effects against hydroxyl radical damage.

Cite This Study

Gökkaya et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056b21https://doi.org/10.1002/bmc.70512
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