What question did this study set out to answer?

Assess the feasibility, efficacy, and safety of anti-CD19 CAR-T therapy for systemic sclerosis relapses following autologous hematopoietic stem cell transplantation.

April 7, 2026Lara D. Veeken

Anti-CD19 CAR-T cell therapy as rescue treatment in systemic sclerosis relapsing after autologous hematopoietic stem cell transplantation: a case series

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Authors

DRDoron Rimar PDPaula DavidTel Aviv University EJElad Jacoby

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Implication

Case series shows anti-CD19 CAR-T therapy improves outcomes in systemic sclerosis relapses, suggesting new rescue options.

Key Points

Assess the feasibility, efficacy, and safety of anti-CD19 CAR-T therapy for systemic sclerosis relapses following autologous hematopoietic stem cell transplantation.
Thirty systemic sclerosis patients underwent autologous hematopoietic stem cell transplantation (AHSCT).
Relapse defined by increased modified Rodnan skin score (mRSS) ≥25% or decreased forced vital capacity (FVC) ≥10%.
Three female patients received anti-CD19 CAR-T cells after lymphodepletion with fludarabine and cyclophosphamide.
Two patients improved with FVC increase (≥10%) and ≥25% reduction in mRSS.
One patient showed no response due to lack of CAR-T expansion.
Adverse events were mild, with grade 1 cytokine release syndrome noted.

Cite This Study

Rimar et al. (2026) studied this question.

synapsesocial.com/papers/69d49fa9b33cc4c35a2280df https://doi.org/10.1093/rheumatology/keag173

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Anti-CD19 CAR-T cell therapy as rescue treatment in systemic sclerosis relapsing after autologous hematopoietic stem cell transplantation: a case series

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Cite This Study

Anti-CD19 CAR-T cell therapy as rescue treatment in systemic sclerosis relapsing after autologous hematopoietic stem cell transplantation: a case series

Discussion

Member takes

Implication

Key Points

Cite This Study

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