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August 2, 2026Arthritis Care & Research

Adopting a Standard of Care for Systemic Sclerosis: The Mayo Clinic Experience

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Authors

EAErnesto AyalaJacksonville CollegeMIMadiha IqbalMayo Clinic in FloridaTMTristan MeierMayo Clinic in Arizona

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Implication

Retrospective analysis shows improved survival outcomes in severe systemic sclerosis with autoHCT, suggesting a new standard of care.

Key Points

  • This study evaluates the outcomes of implementing autologous hematopoietic cell transplantation (autoHCT) for patients with severe systemic sclerosis.
  • Retrospective analysis of consecutive patients undergoing autoHCT from April 1, 2020, to December 31, 2023.
  • Eligibility included progressive systemic sclerosis despite standard immunosuppressive therapy.
  • Primary endpoints were overall survival and event-free survival.
  • At 23 months median follow-up, 2-year overall survival was 91.67% (95% CI 81.25-100.0) and event-free survival was 74.51% (95% CI 58.78-94.45).
  • The 2-year cumulative incidence of relapse was 23.93% (95% CI 4.27 -43.59) and non-relapse mortality was 8.33% (95% CI 2.97 -19.64).
  • Significant improvement in modified Rodnan Skin Score at days +90 and +180 (p<0.05).

Cite This Study

Ayala et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb101b0468a7eeab3eeehttps://doi.org/10.1002/acr.80129
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Also Consider

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  1. 12013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative2013 · 3,455 citations
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  5. 5Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases2009 · 364 citations