Prognostic Value of Impaired Hepato-Renal Function and Liver Fibrosis in Patients Admitted for Acute Heart Failure

Figure 1. Flow of patients through the study. HFmrEF, heart failure with mid‐range ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction.

Figure 2. (A) All‐cause, (B) cardiac, and (C) non‐cardiac death free rate curves in patients with acute decompensated heart failure stratified by the median value of model for end‐stage liver disease excluding international normalized ratio score (MELD‐XI) and fibrosis‐4 index (FIB‐4) (overall cohort). Median value of MELD‐XI and FIB‐4 was 11 and 2.13, respectively.

Figure 3. The receiver operating characteristic curve analysis for the prediction of (A) all‐cause, (B) cardiac, and (C) non‐cardiac death. CI, confidence interval; FIB‐4, fibrosis‐4 index; MELD‐XI, model for end‐stage liver disease excluding international normalized ratio score.

Figure 4. (A–C) All‐cause, (D–F) cardiac, and (G–I) non‐cardiac death free rate curves in patients with acute decompensated heart failure with heart failure with reduced ejection fraction (HFrEF), heart failure with mid‐range ejection fraction (HFmrEF), and heart failure with preserved ejection fraction (HFpEF) stratified by the median value of model for end‐stage liver disease excluding international normalized ratio score (MELD‐XI) and fibrosis‐4 index (FIB‐4). In patients with HFrEF, median value of MELD‐XI and FIB‐4 was 11 and 2.18, respectively. In patients with HFmrEF, median value of MELD‐XI and FIB‐4 was 11 and 2.20, respectively. In patients with HFpEF, median value of MELD‐XI and FIB‐4 was 11 and 1.98, respectively.