Why the study?
Because measuring coronary artery calcification involves radiation exposure, identifying biomarkers such as cardiac troponins associated with CAC could help identify high-risk individuals and provide insight into CAC pathophysiology.
Are elevated cardiac troponins associated with the occurrence and severity of coronary artery calcification?
Are elevated cardiac troponins associated with the occurrence and severity of coronary artery calcification?
Cardiac troponins T and I are correlated with the occurrence and severity of coronary artery calcification, suggesting they could serve as useful biomarkers to identify individuals at high risk for subclinical atherosclerosis.
Troponins may help stratify subclinical atherosclerosis risk; extends observational data linking levels to CAC severity while highlighting age/gender modifiers.
An early diagnosis of atherosclerosis, particularly in subclinical status, can play a remarkable role in reducing mortality and morbidity. Because of coronary artery calcification (CAC) nature in radiation exposure, finding biomarkers associated with CAC could be useful in identifying individuals at high risk of CAC score. In this review, we focused on the association of cardiac troponins (hs-cTns) and CAC to achieve insight into the pathophysiology of CAC. In October 2022, we systematically searched Web of Science, Scopus, PubMed, and Embase databases to find human observational studies which have investigated the association of CAC with cardiac troponins. To appraise the included articles, we used the Newcastle Ottawa scale (NOS). Out of 520 records, 10 eligible studies were included. Based on findings from longitudinal studies and cross-sectional analyses, troponin T and I were correlated with occurrence of CAC and its severity. Two of the most important risk factors that affect the correlation between hs-cTns serum levels and CAC were age and gender. The elevation of cardiac troponins may affect the progression of CAC and future cardiovascular diseases. Verifying the association between cardiac troponins and CAC may lead to identify individuals exposed to enhanced risk of cardiovascular disease (CVD) complications and could establish innovative targets for pharmacological therapy.
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Shahraki et al. (2024) studied this question.
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