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April 29, 2021SHILAP Revista de lepidopterologíaOpen Access

ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

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Why the study?

The relationship between COVID-19 and atherosclerosis is of interest given that the renin-angiotensin system, particularly ACE2, plays an essential role in both conditions.

Design

Narrative review

Authors

APAnastasia V. PoznyakInstitute for Atherosclerosis ResearchEBEvgeny E. BezsonovVascular MedicineAEAli H. EidSuez University

Discussion

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Implication

Supports mechanistic link between COVID-19 and atherosclerosis via ACE2; leaves open need for prospective trials before clinical application.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Poznyak et al. (2021) studied this question.

synapsesocial.com/papers/69d56c2175589c71d767cbf4https://doi.org/10.3390/ijms22094691

Topics

COVID-19 cardiovascular
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis2008 · 310 citations
  2. 2Immunolocalization of ACE2 and AT 2 Receptors in Rabbit Atherosclerotic Plaques2005 · 60 citations
  3. 3Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China2020 · 21,248 citations
  4. 4Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats2015 · 57 citations
  5. 5ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis2014 · 29 citations