June 15, 2005Journal of General Virology

Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation

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Structured PICO

Population

Foot-and-mouth disease virus (FMDV) serotype A1061 (a cell culture-adapted strain)

Outcome

Crystal structure of FMDV A10(61) complexed with heparin

The crystal structure of FMDV A10(61) reveals that despite antigenic variation, the heparin receptor binding site is conserved, though with altered binding affinity.

Discussion

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Implication

Conserved FMDV receptor site across variants; leaves open whether this informs vaccine or host-range studies.

Cite This Study

Elizabeth E. Fry (2005) studied this question.

synapsesocial.com/papers/69d56cee75589c71d767ceca https://doi.org/10.1099/vir.0.80730-0

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Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation

Structured PICO

Discussion

Implication

Cite This Study

Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider