Why the study?
Does bilateral renal denervation reduce sympathetic drive and restore nNOS in the paraventricular nucleus in rats with heart failure?
Population
Rats with heart failure (HF) induced by ligation of the left coronary artery
Comparison
Bilateral renal denervation performed 4 weeks… vs Sham group
Design
Preclinical
Authors
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Does not support RDN in human HF; leaves open whether PVN nNOS restoration mediates sympathoexcitation.
Does bilateral renal denervation reduce sympathetic drive and restore nNOS in the paraventricular nucleus in rats with heart failure?
Renal denervation attenuates sympathoexcitation in heart failure rats by restoring neuronal nitric oxide synthase in the paraventricular nucleus.
Patel et al. (2016) studied this question.
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