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June 4, 2020Scientific ReportsOpen Access

Specific Electrogram Characteristics Identify the Extra-Pulmonary Vein Arrhythmogenic Sources of Persistent Atrial Fibrillation – Characterization of the Arrhythmogenic Electrogram Patterns During Atrial Fibrillation and Sinus Rhythm

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Why the study?

Do specific electrogram characteristics identify extra-pulmonary vein arrhythmogenic sources of persistent atrial fibrillation?

Population

21 patients with clinical persistent atrial fibrillation in whom low-voltage-guided ablation after pulmonary…

Comparison

Analysis of electrogram characteristics at 21… vs 105 targeted sites without AF-termination and…

Design

Cohort

Authors

AJAmir JadidiMNMark NothsteinJCJuan Chen

Discussion

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Overview

EGM features may identify extra-PV sources; hypothesis-generating and requires randomized validation before guiding ablation.

Structured PICO

Do specific electrogram characteristics identify extra-pulmonary vein arrhythmogenic sources of persistent atrial fibrillation?

P
Population
21 patients with clinical persistent atrial fibrillation in whom low-voltage-guided ablation after pulmonary vein isolation terminated AF (short RF-delivery <8sec associated with acute termination).
I
Intervention
Analysis of electrogram (EGM) characteristics at 21 AF-termination sites (AFTS).
C
Comparator
105 targeted sites without AF-termination and 105 non-targeted control sites.
O
Outcome
Electrogram (EGM) characteristics including EGM-voltage, EGM-cycle-length-coverage, AF-cycle-length, and pattern consistency.surrogate

AF-termination sites in persistent atrial fibrillation can be identified by specific electrogram characteristics, including locally consistent, fractionated low-voltage EGMs with high cycle-length-coverage and rapid activity.

Cite This Study

Jadidi et al. (2020) studied this question.

synapsesocial.com/papers/69d56cf075589c71d767cee1https://doi.org/10.1038/s41598-020-65564-2
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