Key result
Fixed C-EGMs ablation is associated with ~57% lower arrhythmia recurrence versus linear ablation in persistent AF.
Why the study?
Complex electrograms during sinus rhythm in AF patients could be pathological or not, and whether local pacing helps discern pathological complex electrograms was unknown.
Does fixed C-EGMs ablation reduce recurrence in persistent AF patients compared with linear ablation?
Cohort (n=153)
No
Does fixed C-EGMs ablation reduce recurrence in persistent AF patients compared with linear ablation?
Effect estimate: HR 0.43 (95% CI 0.21-0.81)
Absolute Event Rate: 28.9% vs 52.4%
p-value: p=0.011
Identifying and targeting fixed complex electrograms via local pacing improves ablation outcomes and reduces recurrence in patients with persistent atrial fibrillation compared to linear ablation.
No takes yet. Share an insight, caveat, or question.
Fixed C-EGMs ablation was associated with lower recurrence in persistent AF; hypothesis-generating and should not yet change practice.
Xu et al. (2022) conducted a cohort in Persistent atrial fibrillation (n=153). Fixed C-EGMs ablation vs. Linear ablation was evaluated on AT/AFL/AF recurrence (HR 0.43, 95% CI 0.21-0.81, p=0.011). Fixed C-EGMs ablation significantly reduced the risk of atrial tachyarrhythmia recurrence by 57% compared to linear ablation in patients with persistent atrial fibrillation (HR 0.43).
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