Why the study?
What is the effect of age and sex on echocardiographic left ventricular diastolic function parameters in patients with preserved ejection fraction and normal valvular function?
What is the effect of age and sex on echocardiographic left ventricular diastolic function parameters in patients with preserved ejection fraction and normal valvular function?
Current normal reference values for diastolic function parameters, particularly the E/e ratio, may need to be adjusted for age and sex.
Hypothesis-generating for age- and sex-adjusted E/e' references in preserved EF; prospective validation required before practice change.
To our knowledge, this is the most imposing study - in terms of number of patients from first to tenth decade of life that were included - addressing the effect of age and gender on diastolic function. Our results stress the need for future prospective trials to establishnormal diastolic function parameters according to age and gender, notably for the E/e ratio for which a significant proportion of our population had a ratio superior of what is actually considered normal.
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Carvalho et al. (2013) studied this question.
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