What question did this study set out to answer?

To evaluate the impact of intensive glycaemic control versus conventional therapy and tight versus less tight blood pressure control on vascular complications and mortality in type 2 diabetes.

November 1, 1999British Journal of Clinical PharmacologyOpen Access

The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes

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Authors

PKP. KingRoyal Derby Hospital IPIan PeacockChicago Kent College of Law RDRichard DonnellyUniversity of Nottingham

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Implication

Randomized trial demonstrates that tight blood pressure and intensive glucose control reduce complications in type 2 diabetes, indicating distinct benefits for macrovascular and microvascular health.

Key Points

To evaluate the impact of intensive glycaemic control versus conventional therapy and tight versus less tight blood pressure control on vascular complications and mortality in type 2 diabetes.
Multicenter randomized trial across 23 UK centers following 5,102 patients for a median of 10 years, comparing intensive glucose control (fasting plasma glucose target 6 mmol/L) with conventional therapy (<15 mmol/L) using diet, sulfonylureas, insulin, or metformin.
Embedded randomized trial in 1,148 hypertensive patients comparing tight blood pressure control (target <150/85 mm Hg) using captopril or atenolol against less tight control (<180/105 mm Hg).
Intensive glucose control achieved a 0.9% HbA1c reduction and significantly decreased any diabetes-related endpoint, primarily driven by a 25% reduction in microvascular complications, but showed no statistically significant reduction in myocardial infarction or overall mortality.
Tight blood pressure control achieved a mean pressure of 144/82 mm Hg versus 154/87 mm Hg, significantly reducing diabetes-related mortality and morbidity, cutting strokes and heart failure by 50% and microvascular disease by approximately one-third, with captopril and atenolol exhibiting comparable efficacy.

Cite This Study

King et al. (1999) studied this question.

synapsesocial.com/papers/69d56cf575589c71d767cf27 https://doi.org/10.1046/j.1365-2125.1999.00092.x

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Implication

Randomized trial demonstrates that tight blood pressure and intensive glucose control reduce complications in type 2 diabetes, indicating distinct benefits for macrovascular and microvascular health.

The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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