The Evidence Base for Tight Blood Pressure Control in the Management of Type 2 Diabetes Mellitus

Persons with type 2 diabetes who have hypertension, defined as systolic blood pressure of at least 140 mm Hg or diastolic blood pressure of at least 90 mm Hg, including those with microvascular complications and premenopausal women.

Tight blood pressure control (e.g., target diastolic blood pressure of 80 mm Hg) and use of specific antihypertensive agents (such as ACE inhibitors).

Less tight blood pressure control, placebo, or usual care.

Clinical end points including all-cause mortality, cardiovascular mortality, cardiovascular events (myocardial infarction, stroke, or congestive heart failure), and microvascular complications (photocoagulation, nephropathy, neuropathy, or amputation).hard clinical