October 1, 2007

Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?

Structured PICO

Does SSRI treatment reduce sympathetic activity in patients with major depressive disorder?

P

Population

Patients with major depressive disorder (MDD) with extraordinarily high sympathetic nervous activity

I

Intervention

Selective serotonin reuptake inhibitor (SSRI)

O

Outcome

Sympathetic nervous activitysurrogate

SSRI treatment may reduce sympathetic nervous activity in a subset of MDD patients, potentially lowering their cardiac risk.

Abstract

We have identified a subset of patients with MDD in whom sympathetic nervous activity is extraordinarily high, including in the sympathetic outflow to the heart. Treatment with an SSRI may reduce sympathetic activity in a manner likely to reduce cardiac risk.

Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?

Structured PICO

Abstract

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Also Consider

Also Consider