What question did this study set out to answer?

To develop and evaluate a noninvasive targeted radiotracer imaging strategy for in vivo visualization of matrix metalloproteinase (MMP) activation and tracking of post-infarction remodeling.

November 8, 2005CirculationOpen Access

Noninvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Postinfarction Remodeling

View Full Paper

Ask AI

Bookmark

Population

Murine model of postinfarction remodeling

Design

Preclinical

Authors

HSHaili SuHohhot First Hospital FSFrancis G. SpinaleHeart Failure & Transplant LDLawrence W. DobruckiUniversity of Illinois Urbana-Champaign

Discussion

Member takes

Implication

Provides proof-of-concept for noninvasive MMP imaging in murine post-MI remodeling; leaves open clinical translation and diagnostic utility.

Key Points

To develop and evaluate a noninvasive targeted radiotracer imaging strategy for in vivo visualization of matrix metalloproteinase (MMP) activation and tracking of post-infarction remodeling.
Utilized a murine model of post-myocardial infarction cardiac remodeling.
Administered a novel targeted MMP radiotracer to perform noninvasive in vivo molecular imaging.
Achieved successful in vivo noninvasive localization of active matrix metalloproteinases within remodeling cardiac tissue.
Demonstrated feasibility for longitudinal monitoring and tracking of MMP-driven post-infarction structural remodeling.

Structured PICO

Population

Murine model of postinfarction remodeling

Intervention

Noninvasive targeted MMP radiotracer imaging

Outcome

In vivo localization of MMP activation and tracking of MMP-mediated post-MI remodelingsurrogate

A novel targeted MMP radiotracer imaging approach shows potential for tracking post-MI remodeling in a murine model.

Cite This Study

Su et al. (2005) studied this question.

synapsesocial.com/papers/69d56d2b75589c71d767cfd3 https://doi.org/10.1161/circulationaha.105.583021

View Full Paper

Ask AI

Bookmark

Implication

Provides proof-of-concept for noninvasive MMP imaging in murine post-MI remodeling; leaves open clinical translation and diagnostic utility.

Noninvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Postinfarction Remodeling

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Noninvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Postinfarction Remodeling

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider