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February 1, 1962Circulation Research

Mechanism of Ventricular Fibrillation in Hypothermia

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Population

Hearts subjected to hypothermia

Design

Preclinical

Authors

BCBenjamín G. CovinoBoston CollegeHDHenry E. D'AmatoBoston University

Discussion

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Overview

Supports size-dependent VF mechanisms in hypothermia; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Hearts subjected to hypothermia
I
Intervention
Hypothermia, sympathomimetic amines, and physical shortening of the conduction pathway
O
Outcome
Mechanism and incidence of ventricular fibrillationsurrogate

The circus movement theory explains hypothermia-induced ventricular fibrillation, highlighting the critical role of decreased conduction velocity and heart size.

Cite This Study

Covino et al. (1962) studied this question.

synapsesocial.com/papers/69d56dc075589c71d767d024https://doi.org/10.1161/01.res.10.2.148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Related to the Initiation of Ventricular Fibrillation in the Isolated Heart: Effect of Calcium and Potassium1954 · 88 citations
  2. 2Myocardial metabolic and electrical properties of rabbits and ground squirrels at low temperatures1959 · 24 citations
  3. 3Effect of Temperature on the Heart Rate, Electrocardiogram and Certain Myocardial Oxidations of the Rat1958 · 25 citations
  4. 4Electrophysiology of the Heart1962 · 74 citations
  5. 5Possible Reasons for Drop of Resting Potential of Mammalian Heart Preparations During Hypothermia1960 · 53 citations