Key result
Numerical simulations demonstrated that fibrillation is easier to induce at low temperatures, requires a temperature-dependent minimum tissue size, and decreases in frequency with cooling.
Population
Two-dimensional numerical simulations using a minimal mathematical model of cardiac action potential…
Comparison
Simulated hypothermia/temperature variations and… vs Simulations at different temperatures
Design
Preclinical
Authors
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May increase VF risk during cooling in models; leaves open clinical relevance of tissue-size dependence.
Computational modeling reveals that hypothermia facilitates ventricular fibrillation induction and that the arrhythmogenic effect of regional cooling depends on tissue size.
Filippi et al. (2014) studied Hypothermic ventricular fibrillation. Numerical simulations of temperature variation was evaluated on Mechanisms of fibrillation induction during hypothermia. Numerical simulations demonstrated that fibrillation is easier to induce at low temperatures, requires a temperature-dependent minimum tissue size, and decreases in frequency with cooling.
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