Why the study?
Hypothermia is used therapeutically and occurs accidentally, with ventricular arrhythmias causing high mortality, prompting a review of the effect of hypothermia on cardiac electrophysiology.
What is the effect of hypothermia on cardiac electrophysiology in clinical and experimental settings?
Population
Clinical and experimental literature on the effect of hypothermia on cardiac electrophysiology
Comparison
Hypothermia vs normothermia or progressive cooling
Design
Systematic review
Authors
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Severe hypothermia promotes ventricular arrhythmias; leaves open optimal temperature targets in therapeutic protocols.
What is the effect of hypothermia on cardiac electrophysiology in clinical and experimental settings?
Hypothermia progressively alters cardiac electrophysiology, notably prolonging the QT interval and increasing the risk of severe ventricular arrhythmias, suggesting QT-prolonging drugs should be avoided.
Dietrichs et al. (2018) studied this question.
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