Key result
Moderate hypothermia at 32°C is linked to an ~57 ms wider electromechanical window vs 36°C.
Why the study?
Whether electrophysiological and mechanical changes observed experimentally occur in humans during moderate hypothermia had not been previously explored.
Does moderate hypothermia alter myocardial electrophysiological and mechanical relationships in patients with normal left ventricular function?
Observational (n=20)
Single-blind
No
Does moderate hypothermia alter myocardial electrophysiological and mechanical relationships in patients with normal left ventricular function?
Absolute Event Rate: 86% vs 29%
p-value: p=<0.001
Moderate hypothermia increases electromechanical window positivity without altering dispersion of repolarization or mechanical dispersion, suggesting a potentially favorable electrophysiological profile that may be relevant for post-cardiac arrest patients.
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May support favorable profile during cooling in normal LV function; leaves open relevance for post-arrest hypothermia pending prospective trials.
Wisløff‐Aase et al. (2022) conducted an observational in Normal left ventricular function undergoing elective ascending aortic surgery (n=20). Moderate hypothermia vs. Baseline normothermia (36°C) was evaluated on Electromechanical window (time difference between mechanical and electrical systole) at spontaneous heart rate (p=<0.001). Moderate hypothermia at 32°C significantly increased electromechanical window positivity (86 ms vs 29 ms, p<0.001) compared to 36°C, while dispersion of repolarization remained unchanged.
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