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October 1, 1990Journal of Clinical Oncology

Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study.

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Why the study?

Does the addition of doxorubicin or bilateral pulmonary radiotherapy to VAC and primary radiotherapy improve relapse-free survival in children with primary, nonmetastatic Ewing's sarcoma of bone?

Population

342 previously untreated eligible children with primary, nonmetastatic Ewing's sarcoma of bone

Comparison

Treatment 1: radiotherapy to primary lesion plus… vs Treatment 2: radiotherapy to primary lesion plus…

Design

RCT, Randomized between treatment 1 or treatment 2, or between treatment 2 or…

Follow-up

5 years

Authors

MNM. NesbitThe Wistar InstituteEGE. GehanGeorgetown UniversityEBE. Omer BurgertMayo Clinic

Discussion

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Implication

Supports doxorubicin addition to VAC plus radiotherapy for nonmetastatic Ewing sarcoma; confirms RFS benefit versus VAC alone in this RCT.

Structured PICO

Does the addition of doxorubicin or bilateral pulmonary radiotherapy to VAC and primary radiotherapy improve relapse-free survival in children with primary, nonmetastatic Ewing's sarcoma of bone?

P
Population
342 previously untreated eligible children with primary, nonmetastatic Ewing's sarcoma of bone
I
Intervention
Treatment 1: radiotherapy to primary lesion plus cyclophosphamide, vincristine, dactinomycin, and doxorubicin (VAC plus ADR); or Treatment 3: VAC plus bilateral pulmonary radiotherapy (VAC plus BPR)
C
Comparator
Treatment 2: radiotherapy to primary lesion plus cyclophosphamide, vincristine, and dactinomycin (VAC alone)
O
Outcome
Relapse-free survival (RFS) at 5 yearshard clinical

The addition of doxorubicin to standard VAC chemotherapy and primary radiotherapy significantly improves relapse-free and overall survival in children with primary, nonmetastatic Ewing's sarcoma of bone.

Cite This Study

Nesbit et al. (1990) studied this question.

synapsesocial.com/papers/69d56dc375589c71d767d048https://doi.org/10.1200/jco.1990.8.10.1664
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The response of Ewing's sarcoma to sequential cyclophosphamide and adriamycin induction therapy.1983 · 85 citations
  2. 2Therapy for localized Ewing's sarcoma of bone.1989 · 180 citations