Why the study?
Does risk-stratified intensified chemotherapy improve survival in patients with Ewing's sarcoma of bone?
Population
144 patients with previously untreated Ewing's sarcoma of bone
Comparison
Risk-stratified chemotherapy protocols vs Historical treatment protocols (before 1982)
Design
Cohort
Follow-up
5 years
Authors
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Risk-stratified protocols were associated with higher survival; hypothesis-generating and requires randomized trials before changing practice.
Does risk-stratified intensified chemotherapy improve survival in patients with Ewing's sarcoma of bone?
Risk-stratified intensified chemotherapy protocols improved 5-year survival rates in patients with Ewing's sarcoma, particularly for high-risk patients.
Marcus et al. (2002) studied this question.
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