Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease
Why the study?
Does warfarin treatment reduce stroke or systemic thromboembolism and affect bleeding risk in patients with atrial fibrillation and chronic kidney disease?
Population
Patients with atrial fibrillation and chronic kidney disease
Design
Cohort
Authors
Discussion
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Member takes
Implication
May inform anticoagulation decisions in AF-CKD but requires bleeding risk weighing, especially with aspirin; leaves open net benefit confirmation in RCTs.
Structured PICO
Does warfarin treatment reduce stroke or systemic thromboembolism and affect bleeding risk in patients with atrial fibrillation and chronic kidney disease?
P
Population
Patients with atrial fibrillation and chronic kidney disease
I
Intervention
Warfarin treatment; aspirin
O
Outcome
Stroke or systemic thromboembolism, and bleedinghard clinical
In patients with atrial fibrillation and chronic kidney disease, warfarin is associated with reduced stroke risk but increased bleeding risk, particularly when combined with aspirin.
Cite This Study
Olesen et al. (2012) studied this question.