⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

January 2, 2013Journal of Clinical InvestigationOpen Access

Calcium cycling proteins and heart failure: mechanisms and therapeutics

View Full Paper

Ask AI

Bookmark

Share

Design

Review

Authors

AMAndrew R. MarksElectrophysiology

Discussion

Loading...

Member takes

Implication

Supports targeting RyR2 and SERCA2a in ongoing HF trials; leaves open proof of clinical benefit.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Andrew R. Marks (2013) studied this question.

synapsesocial.com/papers/69d56dff75589c71d767d29c https://doi.org/10.1172/jci62834

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure2003 · 263 citations
2β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure2003 · 312 citations
3Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling2004 · 216 citations
4PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)2000 · 1,991 citations
5Ryanodine receptor studies using genetically engineered mice2010 · 49 citations