What question did this study set out to answer?

To review the mechanisms by which hemodynamic shear stresses are transmitted and transduced by the vascular endothelium into biophysical, biochemical, and gene regulatory responses.

July 1, 1995Physiological ReviewsOpen Access

Flow-mediated endothelial mechanotransduction

View Full Paper

Ask AI

Bookmark

Authors

PDPeter F. DaviesStevens Institute of Technology

Discussion

Member takes

Implication

Review reveals mechanisms of endothelial mechanotransduction under shear stress in blood vessels, highlighting pathways governing vascular tone and atherosclerosis.

Key Points

To review the mechanisms by which hemodynamic shear stresses are transmitted and transduced by the vascular endothelium into biophysical, biochemical, and gene regulatory responses.
Synthesized findings on the transmission of fluid mechanical forces throughout endothelial cell layers.
Evaluated endothelial mechanotransduction pathways that modulate vascular tone, arterial wall remodeling, and focal lesion localization.
Hemodynamic shear stresses directly regulate acute changes in vascular tone and direct long-term structural remodeling of arterial walls.
Mechanical forces act through biophysical and biochemical signaling cascades that control endothelial gene expression and dictate the localization of atherosclerotic lesions.

Cite This Study

Peter F. Davies (1995) studied this question.

synapsesocial.com/papers/69d56e0475589c71d767d2cd https://doi.org/10.1152/physrev.1995.75.3.519

View Full Paper

Ask AI

Bookmark

Implication

Review reveals mechanisms of endothelial mechanotransduction under shear stress in blood vessels, highlighting pathways governing vascular tone and atherosclerosis.

Flow-mediated endothelial mechanotransduction

Discussion

Member takes

Implication

Key Points

Cite This Study

Flow-mediated endothelial mechanotransduction

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider