Why the study?
Does resistance training prevent doxorubicin-induced cardiac dysfunction in rats?
Population
Rats
Comparison
Resistance training for 12 weeks followed by… vs Sedentary for 12 weeks followed by 12.5 mg/kg…
Design
Preclinical
Follow-up
5 days post-doxorubicin exposure
Authors
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Hypothesis-generating for resistance training against doxorubicin cardiotoxicity in rats; leaves open translation to patients.
Does resistance training prevent doxorubicin-induced cardiac dysfunction in rats?
In a rat model, 12 weeks of resistance training protected against doxorubicin-induced cardiac dysfunction, potentially by preserving cardiac MHC isoform distribution.
Pfannenstiel et al. (2018) studied this question.
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