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December 28, 2023Circulation Arrhythmia and ElectrophysiologyOpen Access

Effects of Contact Force on Lesion Size During Pulsed Field Catheter Ablation: Histochemical Characterization of Ventricular Lesion Boundaries

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Why the study?

Does increasing contact force increase lesion depth during pulsed field catheter ablation in ventricular tissue?

Comparison

PFA at different levels of CF at the same PFA dose

Authors

HNHiroshi NakagawaQCQuim CastellvíRNRobert E. Neal

Discussion

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Overview

May influence ventricular PFA lesion depth; hypothesis-generating and requires clinical validation.

Structured PICO

Does increasing contact force increase lesion depth during pulsed field catheter ablation in ventricular tissue?

P
Population
Ventricular tissue undergoing pulsed field catheter ablation
I
Intervention
Pulsed field ablation (PFA) with varying contact force (CF)
C
Comparator
Different levels of contact force at the same PFA dose
O
Outcome
Lesion size/depth and histochemical characterization of boundaries (irreversible vs reversible) by triphenyl tetrazolium chloride stainingsurrogate

Electrode-tissue contact force is required for effective lesion formation during pulsed field ablation, and increasing contact force significantly increases lesion depth.

Cite This Study

Nakagawa et al. (2023) studied this question.

synapsesocial.com/papers/69d56ec275589c71d767d5ebhttps://doi.org/10.1161/circep.123.012026
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