June 21, 2012Platelets

Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms

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Why the study?

Is clopidogrel resistance associated with P2Y1 and P2Y12 gene polymorphisms in North Indian patients with coronary artery disease?

Population

100 North Indian patients with coronary artery disease on maintenance dose of clopidogrel with or without…

Comparison

Assessment of platelet aggregation response to… vs Two groups of controls used for defining cut-off…

Design

Cohort

Authors

RKRakhee KarJawaharlal Institute of Post Graduate Medical Education and Research AMArvind MeenaGuru Gobind Singh Indraprastha University BYBirendra Kumar YadavPurbanchal University

Discussion

Member takes

Implication

Clopidogrel resistance rates should not alter prescribing in North Indian CAD patients; leaves open multifactorial etiology beyond P2Y1/P2Y12 polymorphisms.

Structured PICO

Is clopidogrel resistance associated with P2Y1 and P2Y12 gene polymorphisms in North Indian patients with coronary artery disease?

Population

100 North Indian patients with coronary artery disease (CAD) on maintenance dose of clopidogrel (75 mg OD) with or without aspirin, including 10 who received a loading dose (300 mg) prior to percutaneous coronary intervention.

Intervention

Assessment of platelet aggregation response to clopidogrel and genotyping for P2Y1 (1622A > G) and P2Y12 (i-T744C) gene polymorphisms.

Comparator

Two groups of controls used for defining cut-off for platelet aggregation response.

Outcome

Clopidogrel resistance (platelet aggregation response) and its association with P2Y1 and P2Y12 gene polymorphisms.surrogate

Clopidogrel resistance is present in a significant minority of North Indian CAD patients but is not driven by single-gene polymorphisms of the P2Y1 and P2Y12 receptors, suggesting a multifactorial etiology.

Cite This Study

Kar et al. (2012) studied this question.

synapsesocial.com/papers/69d56ec475589c71d767d610 https://doi.org/10.3109/09537104.2012.693992

Topics

Dual antiplatelet therapy Coronary artery disease

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Bookmark

Implication

Clopidogrel resistance rates should not alter prescribing in North Indian CAD patients; leaves open multifactorial etiology beyond P2Y1/P2Y12 polymorphisms.

Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider